Fig. 5. Effect of KIF15 knockdown on AKT and p53-dependent pathway of NPC cell lines.
(A) The protein expression of p-AKT, AKT (B), P53 (C), MMP2 (E), and MMP9 (G) were detected in KIF15-shRNA/CNE-2 and ScrshRNA/CNE-2 cell lines. (H) The protein expression of p-AKT, AKT (I), P53 (J), MMP2 (L), and MMP9 (N) were detected in KIF15-shRNA/CNE-2 and ScrshRNA/CNE-2 cell lines. The mRNA expression of MMP2 (D, F) and MMP9 (K, M) were detected. Values are presented as mean ± SD. KIF15, kinesin superfamily member 15; NPC, nasopharyngeal carcinoma. *p < 0.05 and **p < 0.01 vs. the shcontrol group, n = 5.
© Korean J Physiol Pharmacol
