Fig. 3. Memantine and ifenprodil activate autophagy in ARPE-19 cells.
(A) ARPE-19 cells were treated with 1, 10, and 25 μM memantine for 8 h. LC3-II, p-p62 (S349), p62, and β-actin protein levels were detected using Western blotting. Images were quantified using the Image J software. (B) ARPE-19 cells were treated with 1, 10, and 25 μM ifenprodil for 8 h. Representative results are presented as the mean ± SD. (n = 3). *p < 0.05, **p < 0.01 vs. no-treatment control.
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