Fig. 3. Paeonol promotes M2 macrophage polarization in diabetic ulcers.
Ulcerated DM rats were treated with or without paeonol. (A, B) Western blot was used to detect the expression of inflammatory factors IL-1β, TNF-α, IL-4 and IL-10 and macrophage markers CD86 and CD206 in the ulcers on the 21st day. (C, D) Immunofluorescence was used to detect the expression of iNOS and arginase 1 in the ulcers. Scale bar = 50 μm. The data were expressed as mean ± standard deviation. Each group had 5 rats. *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control group. #p < 0.05, ##p < 0.01, compared with the DM group. DM, diabetes mellitus; IL, interleukin; TNF-α, tumor necrosis factor α.
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