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Fig. 2. Paeonol reduces inflammation and promotes collagen deposition in diabetic ulcers.
Ulcerated DM rats were treated with or without paeonol. (A) H&E assessment of the pathological characteristics of the ulcers. (B) Masson staining for revealing collagen deposition in the ulcers. Immunohistochemical detection of the expression of Ki67 (C), CD31 and VEGF (D). The data were expressed as mean ± standard deviation. Each group had 5 rats. Scale bar = 50 μm. *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control group. #p < 0.05, ###p < 0.001, compared with the DM group. DM, diabetes mellitus; VEGF, vascular endothelial growth factor; IHC, immunohistochemistry.
Korean J Physiol Pharmacol 2023;27:437-448
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