Fig. 1. Schematic lysosomal ion channels and transporters. The ion movements belong to ion channel directions. Lysosomal ion channels characterized permeability; TRPMLs (few divalent cations, and nonselective cations: yellow), TMEM175, BK (potassium ion: blue), ClC-7 (chloride and hydrogen: green), V-ATPase (hydrogen: black), and TPCs (sodium, and calcium: purple). Compared to the cytosol, lysosomal lumen has high concentrations of Na⁺, Ca²⁺, and H⁺ but not K⁺. BK, calcium-activated large-conductance K⁺ channel; TPC, two-pore channel.

Korean J Physiol Pharmacol 2023;27:311-323 https://doi.org/10.4196/kjpp.2023.27.4.311

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