Comparison of action potential parameters between human iPSC-CMs and native human VCMs
| Cell types | RMP (mV) | TA (mV) | dV/dtmax (V/s) | APD90 (ms) | |
|---|---|---|---|---|---|
| Human iPSC-CMs | Nodal-like | –30.5 ± 2.54 | 42.4 ± 3.25 | 6.2 ± 3.77 | 520.5 ± 5.54 |
| Atrial-like | –59.6 ± 1.25 | 96.1 ± 2.54 | 37.1 ± 2.01 | 541.6 ± 3.54 | |
| Ventricular-like | –63.5 ± 1.87 | 120.6 ± 1.21 | 46 ± 1.52 | 730.6 ± 1.01 | |
| Native human VCMs [8] | –81.8 ± 3.3 | 106.7 ± 1.4 | 215 ± 33 | 351 ± 14 | |
Values are expressed as mean ± SEM. iPSC-CMs, induced pluripotent stem cell-derived cardiomyocytes; Native human VCMs, native human ventricular cardiomyocytes; RMP, resting membrane potential; TA, total amplitude; dV/dtmax, maximum upstroke velocity; APD90, action potential duration at 90%.