Table. 1.

Comparison of action potential parameters between human iPSC-CMs and native human VCMs

Cell types RMP (mV) TA (mV) dV/dtmax (V/s) APD90 (ms)
Human iPSC-CMs Nodal-like –30.5 ± 2.54 42.4 ± 3.25 6.2 ± 3.77 520.5 ± 5.54
Atrial-like –59.6 ± 1.25 96.1 ± 2.54 37.1 ± 2.01 541.6 ± 3.54
Ventricular-like –63.5 ± 1.87 120.6 ± 1.21 46 ± 1.52 730.6 ± 1.01
Native human VCMs [8] –81.8 ± 3.3 106.7 ± 1.4 215 ± 33 351 ± 14

Values are expressed as mean ± SEM. iPSC-CMs, induced pluripotent stem cell-derived cardiomyocytes; Native human VCMs, native human ventricular cardiomyocytes; RMP, resting membrane potential; TA, total amplitude; dV/dtmax, maximum upstroke velocity; APD90, action potential duration at 90%.

Korean J Physiol Pharmacol 2023;27:267-275 https://doi.org/10.4196/kjpp.2023.27.3.267
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