Table. 2.

Influence of canagliflozin and puerarin on functional and structural parameters of kidneys in diabetes mice at the end of treatment (22 weeks of age)

Parameter Control Diabetes Can Pue40 Can + Pue40
Kidney weight (mg) 291.3 ± 9.4 462.0 ± 10.3## 342.1 ± 12.0##** 346.7 ± 45.36##** 311.6 ± 4.8**^
Relative kidney weight
(mg/g body weight)
8.8 ± 0.3 11.7 ± 0.3## 10.1 ± 0.4##** 9.5 ± 1.3** 9.5 ± 0.4**
BUN (mg/dl) 8.6 ± 1.0 20.2 ± 1.3## 15.3 ± 0.5##** 14.6 ± 0.9##** 9.5 ± 0.9**^^
Serum creatinine (mg/dl) 0.40 ± 0.04 0.93 ± 0.08## 0.70 ± 0.03##** 0.58 ± 0.10##** 0.47 ± 0.04**^^

Data are presented as the mean ± SD (n = 6). BUN, blood urea nitrogen. ##p < 0.01 vs. Control; **p < 0.01 vs. Diabetes; ^p < 0.05, ^^p < 0.01 vs. Can.

Korean J Physiol Pharmacol 2023;27:221-230 https://doi.org/10.4196/kjpp.2023.27.3.221
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