Influence of canagliflozin and puerarin on functional and structural parameters of kidneys in diabetes mice at the end of treatment (22 weeks of age)
| Parameter | Control | Diabetes | Can | Pue40 | Can + Pue40 |
|---|---|---|---|---|---|
| Kidney weight (mg) | 291.3 ± 9.4 | 462.0 ± 10.3 |
342.1 ± 12.0 |
346.7 ± 45.36 |
311.6 ± 4.8 |
| Relative kidney weight (mg/g body weight) |
8.8 ± 0.3 | 11.7 ± 0.3 |
10.1 ± 0.4 |
9.5 ± 1.3 |
9.5 ± 0.4 |
| BUN (mg/dl) | 8.6 ± 1.0 | 20.2 ± 1.3 |
15.3 ± 0.5 |
14.6 ± 0.9 |
9.5 ± 0.9 |
| Serum creatinine (mg/dl) | 0.40 ± 0.04 | 0.93 ± 0.08 |
0.70 ± 0.03 |
0.58 ± 0.10 |
0.47 ± 0.04 |
Data are presented as the mean ± SD (n = 6). BUN, blood urea nitrogen. ##p < 0.01