Influence of canagliflozin and puerarin on lipid metabolic parameters in diabetes mice at the end of treatment (22 weeks of age)
| Parameter | Control | Diabetes | Can | Pue (mg/kg) | Can + Pue (mg/kg of Pue) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | 10 | 40 | 100 | 4 | 10 | 40 | 100 | |||||
| TC (mM) | 5.15 ± 0.29 | 7.34 ± 0.34 |
6.80 ± 0.15 |
6.88 ± 0.21 |
6.46 ± 0.26 |
6.14 ± 0.23 |
5.47 ± 0.20 |
6.54 ± 0.27 |
6.13 ± 0.22 |
5.25 ± 0.29 |
5.18 ± 0.25 |
|
| LDL-C (mM) |
2.57 ± 0.15 | 3.97 ± 0.08 |
3.54 ± 0.12 |
3.75 ± 0.07 |
3.69 ± 0.08 |
3.12 ± 0.10 |
3.02 ± 0.12 |
3.42 ± 0.09 |
3.22 ± 0.12 |
2.58 ± 0.22 |
2.67 ± 0.29 |
|
| HDL-C (mM) |
2.90 ± 0.08 | 1.97 ± 0.14 |
2.22 ± 0.11 |
2.43 ± 0.19 |
2.49 ± 0.13 |
2.66 ± 0.08 |
2.53 ± 0.08 |
2.56 ± 0.18 |
2.57 ± 0.17 |
2.83 ± 0.08 |
2.86 ± 0.12 |
|
| TG (mM) | 2.33 ± 0.12 | 3.23 ± 0.04 |
3.02 ± 0.08 |
3.03 ± 0.14 |
2.61 ± 0.11 |
2.89 ± 0.08 |
2.19 ± 0.10 |
2.84 ± 0.16 |
2.48 ± 0.14 |
2.36 ± 0.17 |
2.18 ± 0.26 |
|
Data are presented as the mean ± SD (n = 6). TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglyceride. #p < 0.05, ##p < 0.01