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Fig. 2. HPH exacerbates pulmonary damage. (A) Terminal deoxynucleotidyl transferase dUTP nick end labeling was used to reveal pulmonary cell apoptosis (×200). (B) Enzyme-linked immunosorbent assay was performed to detect the expression of TNF-α and IL-6 in serum and lung tissue. (C) The expression of MAD and SOD was measured. (D) Immunohistochemistry was used to reveal the expression of α-SMA in pulmonary arterioles (×200). The data were expressed as mean ± SD. n = 10. HPH, hypoxic pulmonary hypertension; TNF, tumor necrosis factor; IL, interleukin; MAD, malondialdehyde; SOD, superoxide dismutase; α-SMA, α-smooth muscle actin. *p < 0.05 and ***p < 0.001, compared with the control group.
Korean J Physiol Pharmacol 2023;27:209-220
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