Fig. 1. Establishment of an HPH mouse model.
(A) H&E staining was used to reveal the pathological changes of lung tissue and the remodeling of pulmonary vessels (×200). RVSP (B), mPAP (C), and RV / (LV + S) (D) were measured. The data were expressed as mean ± SD. n = 10. HPH, hypoxic pulmonary hypertension; WT, wall thickness; RVSP, right ventricular systolic pressure; mPAP, mean pulmonary artery pressure; RV, right ventricle; LV, left ventricle; S, septum. *p < 0.05 and **p < 0.01, compared with the control group.
© Korean J Physiol Pharmacol
