Fig. 3. Loss of KLF9 suppresses inflammatory response in myocardial tissues after myocardial infarction (MI).
(A) Representative of H&E staining images in myocardial tissues from Klf9 KO or WT mice at day 7 after MI or sham operation (×200). (B) Q-PCR analysis of Il1, Il6 and Tnfa mRNA expression in myocardial tissues from Klf9 KO or WT mice at day 7 after MI. (C) ELISA of IL-1β, IL-6 and TNF-α production in myocardial tissue homogenates from Klf9 KO or WT mice at day 7 after MI. (D) Q-PCR analysis of Il1, Il6 and Tnfa mRNA expression in macrophages isolated from Klf9 KO or WT mice myocardial tissues at day 7 after MI. Data presented as mean ± SD. KO, knockout; WT, wild-type; IL, interleukin; TNF-α, tumor necrosis factor-α. ***p < 0.001. Unpaired Student’s t-test was performed.
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