Fig. 2. KLF9 knockout (KO) alleviates cardiac dysfunction and adverse cardiac remodeling after myocardial infarction (MI).
(A) Q-PCR analysis of Klf9 mRNA expression in macrophages isolated KLF9 KO or littermate control wild-type (WT) mice. (B) Survival curves of Klf9 KO or littermate WT mice subjected to MI or sham operation. (C, D) Echocardiographic measurement of LVEF and LVFS of Klf9 KO or WT mice at baseline (day 0) and the indicated day after MI or sham operation. (E) Representative Masson’s Trichrome staining images in myocardial tissues from Klf9 KO or WT mice at day 28 after MI (×400). Data presented as mean ± SD. LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening. *p < 0.05; **p < 0.01; ***p < 0.001. Unpaired Student’s t-test or ANOVA was performed.
© Korean J Physiol Pharmacol
