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Fig. 7. Resveratrol inhibited pyroptosis via the pathway of TLR4/MyD88/NF-κB. (A) Representative Western blot bands of TLR4, MyD88, p-NF-κB p65. (B) The mRNA levels of TLR4 in each group (n = 8 per group). (C–E) Relative protein expression levels in each group. GAPDH was used for protein expression normalization (n = 3 per group). (F) Representative TLR4 immunofluorescence staining in each group (magnification ×400, scale bar = 100 μm). Low-dose: CME + low-dose RES (25 mg/kg), High-dose: CME + high-dose RES (50 mg/kg). Data were presented as the mean ± SD. TLR4, toll-like receptor 4; MyD88, myeloid differentiation factor 88; NF-κB, nuclear factor-kappa B; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; CME, coronary microembolization; RES, resveratrol. *p < 0.05, compared with Sham group; #p < 0.05, compared with CME group; +p < 0.05, compared with Low-dose group.
Korean J Physiol Pharmacol 2023;27:143-155
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