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Fig. 4. Resveratrol pretreatment attenuated CME-induced mitochondrial injury. (A) Myocardial mitochondrial morphology observed by transmission electron microscopy (magnification ×60,000, scale bar = 500 nm). The black arrows indicate the typical vacuolated degeneration and enlarged mitochondria. (B) ATP concentrations of each group (n = 8 per group). Low-dose: CME + low-dose RES (25 mg/kg), High-dose: CME + high-dose RES (50 mg/kg). Data were presented as the mean ± SD. CME, coronary microembolization; RES, resveratrol. *p < 0.05, compared with Sham group; #p < 0.05, compared with CME group; +p < 0.05, compared with Low-dose group.
Korean J Physiol Pharmacol 2023;27:143-155
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