Fig. 4. MiR-665 is a critical target via which circ_0129047 mediated LUAD tumorigenesis.
PC9 and Calu-3 cells were transfected with circ_0129047 overexpression vectors (OE-circ), OE-NC, miR-665 mimic (mimic) or mimic-NC, and OE+mimic. (A) Cell proliferation was analyzed using the CCK-8 assay. (B) Western blot analysis of anti-Bax and anti-Bcl-2 expression. (C) Colony formation determined using colony formation assay (×200). Values are presented as mean ± SD. LUAD, lung adenocarcinoma; OD, optical density; PTPRB, protein tyrosine phosphatase receptor type B. *p < 0.05, **p < 0.01 vs. OE-NC; #p < 0.05, ##p < 0.01 vs. mimic-NC; &p < 0.05, &&p < 0.01 vs. OE+mimic.
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