Fig. 6. Effects of rosiglitazone on the steady-state inactivation of Kv3.1 currents.
(A) The steady-state inactivation was analyzed using a two-pulse protocol. The currents were induced by a 300-ms pulse to +40 mV while 20-sec preconditioning pulses were varied from –60 to +30 mV using 10-mV steps every 30 sec in the absence and presence of 30 µM rosiglitazone. The dotted lines represent zero current. (B) The steady-state inactivation curves in control (○) and 30 µM rosiglitazone (●) were constructed by normalizing to the peak amplitude after a prepulse and by fitting each set of data with the Boltzmann equation. Data are expressed as means ± SEM.
© Korean J Physiol Pharmacol
