Fig. 5. Use dependence of rosiglitazone-induced inhibition of Kv3.1.
(A) Superimposed Kv3.1 current traces elicited successively with 8 repetitive depolarizing pulses (+40 mV, 300 ms) from a holding potential of –80 mV at 1 Hz in the absence and presence of 30 µM rosiglitazone. The dotted lines represent zero current. (B) Plot of normalized amplitudes of peak currents at 1 (circles) and 2 Hz (triangles), in control (open symbols) and in 30 µM rosiglitazone (closed symbols), against the elapsed time axis. The peak amplitudes were normalized to the peak amplitude of the first current in each condition. (C) With the data in (B), the current amplitude in the presence of rosiglitazone was normalized to the control amplitude at each elapsed time. Data are expressed as mean ± SEM.
© Korean J Physiol Pharmacol
