Fig. 4. Effects of rosiglitazone on the deactivation kinetics of Kv3.1 currents.
Tail currents were elicited with the 150-ms repolarizing pulse of –40 mV after a 300-ms depolarizing pulse of +40 mV, in the absence and presence of 30 µM rosiglitazone. Tail crossover (indicated by arrow) was observed by superimposing two tail currents. The dotted line represents zero current. Inset, the mean value of deactivation time constant (τ) in the presence of rosiglitazone was significantly greater than that in control condition (n = 4; *p < 0.05). Data are expressed as mean ± SEM.
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