Fig. 3. Concentration-dependent kinetics of Kv3.1 inhibition caused by rosiglitazone.
(A) Superimposed Kv3.1 current traces were elicited with +40 mV pulses (300 ms) every 10 sec in the presence of rosiglitazone (10, 30, and 100 µM). The drug-induced time constants were obtained from a single exponential fitting to the decay traces of Kv3.1 currents (solid lines). The dotted line represents zero current. (B) Summary data obtained from A. The time constants (τ) were plotted against rosiglitazone concentrations (n = 4; *p < 0.05 vs. control data). Data are expressed as mean ± SEM.
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