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Fig. 1. Concentration-dependent inhibition of Kv3.1 currents by rosiglitazone. (A) Kv3.1 currents were generated with depolarization of +40 mV (300 ms) from a holding potential of –80 mV, every 10 sec. Currents recorded in the absence and presence of 3, 10, 30, and 100 µM rosiglitazone were superimposed. The dotted line represents zero current. (B) Dose-response curves of rosiglitazone-induced reduction in Kv3.1 currents. The amplitudes of Kv3.1 current were measured at the end (●) and peak (○) of the depolarizing pulses at various concentrations of rosiglitazone. The data of % inhibition (I (%) = [1 – Irosiglitazone / Icontrol] ×100) were fitted with the Hill equation (solid lines). (C) Time course of Kv3.1 inhibition by rosiglitazone. The current amplitudes were measured at the end of a 300-ms depolarizing pulse and normalized to the baseline amplitude. Data are expressed as mean ± SEM.
Korean J Physiol Pharmacol 2023;27:95-103
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