Table. 2.

Comparison of biochemical profile between healthy control subjects and pre-MetS subjects

Variable Total subjects
(n = 182)
Control subjects
(n = 89)
Pre-MetS subjects
(n = 93)
p-value
Glucose profile
FPG (mg/dl) 94.87 (81–109.19) 84.0 (75.0–94.9) 107 (90.0–121.38) 0.001
Insulin (μU/ml) 11.29 (7.79–16.20) 9.65 (6.35–14.21) 12.80 (9.24–17.90) 0.001
HOMA1-IR 2.54 (1.58–4.3) 1.93 (1.15– 2.93) 3.35 (2.03–5.33) 0.001
Lipid profile and lipid ratios (risk factors)
TC (mg/dl) 170.50 (154.0–191.0) 170.0 (153.50–187.60) 171.89 (154.50–195.0) 0.207
TG (mg/dl) 140.00 (123.0–156.7) 125.90 (112.0–138.67) 154.0 (139.57–178.08) 0.001
HDL-c (mg/dl) 43.32 ± 7.70 45.97 ± 5.43 40.78 ± 8.66 0.001
LDL-c (mg/dl) 101.98 (86.30–113.0) 101.96 (88.50–106.60) 102.00 (84.50–127.45) 0.137
VLDL-c (mg/dl) 23 (17.0–30.0) 21.0 (15.72–28.50) 24.0 (18.90–32.94) 0.034
LDL/HDL 2.26 (1.91–2.65) 2.17 (1.87–2.41) 2.50 (1.99–3.35) 0.001
TC/HDL 3.90 (3.41–4.41) 3.71 (3.32–4.03) 4.20 (3.6–5.1) 0.001
TG/HDL 2.90 (2.20–3.40) 2.70 (2.10–3.20) 3.00 (2.46–3.65) 0.003
Non-HDL/HDL 2.90 (2.41–3.44) 2.71 (2.32–3.03) 3.20 (2.51–4.08) 0.001
AIP 0.50 (0.40–0.60) 0.40 (0.30–0.50) 0.50 (0.41–0.64) 0.009
Biomarkers
hs-CRP (mg/l) 11.85 (8.20–14.15) 10.98 (7.02–13.73) 12.25 (9.30–14.53) 0.007
Adiponectin (µg/ml) 12.12 (8.58–18.37) 13.03 (9.15–20.45) 11.20 (8.31–16.05) 0.021

The values are expressed as median (inter-quartile range) or mean ± SD. MetS, metabolic syndrome; FPG, fasting plasma glucose; HOMA-IR, homeostatic model assessment of insulin resistance; TC, total cholesterol; TG, triglyceride; HDL-c, high-density-lipoprotein cholesterol; LDL-c, low-density-lipoprotein cholesterol; VLDL-c, very-low-density lipoprotein cholesterol; AIP, atherogenic index of plasma; hs-CRP, high-sensitive C reactive protein.

Korean J Physiol Pharmacol 2023;27:49-59 https://doi.org/10.4196/kjpp.2023.27.1.49
© Korean J Physiol Pharmacol