Fig. 3. Hydrogen sulfide (H2S) can inactivate the TGF-β1/Smad2 pathway activated by PTU and upregulate the autophagy downregulated by PTU.
(A–C) TGF-β1 and Smad2, p-Smad2 protein expressions among four groups. (D–F) Atg4, Atg5, Beclin1, LC3II/I and P62 protein expressions among four groups. TGF-β1, transforming growth factor-β1; Smad2, SMAD family member 2; PTU, propylthiouracil. *p < 0.05 compared with Control group; #p < 0.05 compared with PTU group.
© Korean J Physiol Pharmacol
