Fig. 8. Sulfur dioxide (SO₂) antagonizes apoptosis of H9c2 cardiomyocytes by down-regulating phosphatidylinositol 3-kinase (PI3K)/AKT and activating autophagy. (A, B) Western blot detection was used to observe the expression changes of autophagy-associated proteins (including LC3II/I, Beclin1, Atg16L1 and P62 of H9c2 cardiomyocytes) in the Control group, the HG group, the HG + SO₂ group, the HG + SO₂ + 740 Y-P group and the SO₂ group. (C–G) Western blot detection was used to observe the expression changes of apoptosis-associated proteins Bax, Bcl2, Caspase3, Cleaved-Caspase3, Caspase9, and Cleaved-Caspase9 of H9c2 cardiomyocytes in the Control, HG, HG + SO₂, HG + SO₂ + 740 Y-P, and SO₂ groups. n = 3. Values are presented as mean ± SD. DC, diabetic cardiomyopathy; HG, high glucose. *p < 0.05 vs. Control. ^#p < 0.05 vs. HG. ^$p < 0.05 vs. HG + SO₂.

Korean J Physiol Pharmacol 2022;26:541-556 https://doi.org/10.4196/kjpp.2022.26.6.541

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