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Fig. 2. The phospholipase C inhibitor U73122 (1 mM) inhibits 0.1 mM [Mg2+]o-induced [Ca2+]i spikes. (A) 0.1 mM [Mg2+]o induced synchronized and repetitive [Ca2+]i spikes within 30 sec at day 11.5. (B) 1 µM U73122 inhibited 0.1 mM [Mg2+]o-induced [Ca2+]i spikes. (C, D) Graph summarizing the frequency (C) and the area under the curve (D) of 0.1 mM [Mg2+]o-induced [Ca2+]i spikes in non-treated (control, n = 25) and U73122-treated (n = 24) cells. Relative spike frequencies or area under curves (2nd / 1st: drug or non-treatment; 3rd / 1st: 0.1 mM [Mg2+]o wash) were shown as a ratio of an initial [Ca2+]i spike frequency and area under curves for 1st 0.1 mM [Mg2+]o treatment. Data are expressed as means ± SEM. **p < 0.01 relative to respective control (non-paired Student’s t-test), *p < 0.05 relative to respective control (non-paired Student’s t-test).
Korean J Physiol Pharmacol 2022;26:531-540
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