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Fig. 6. Activation of JNK reversed neogambogic acid (NGA)-mediated cytokine release in septic mice. (A) Treatment with JNK activator, anisomycin, weakened NGA-induced decrease of p-JNK and p-p38 in heart tissues of lipopolysaccharide (LPS)-induced mice. (B) Treatment with JNK activator, anisomycin, weakened NGA-induced decrease of p-NF-κB in LPS-induced mice. (C) Anisomycin attenuated NGA-induced decrease of interleukin (IL)-1β and IL-6 in LPS-induced mice. ** vs. sham, p < 0.01. ^^ vs. LPS, p < 0.01. ## vs. LPS+NGA, p < 0.01.
Korean J Physiol Pharmacol 2022;26:511-518 https://doi.org/10.4196/kjpp.2022.26.6.511
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