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Fig. 12. Schematic summary of the transcriptional cascades regulating expression of proteins associated with renin secretory phenotypes in As4.1 cells. N-cad expression at the plasma membrane upon cell-cell contact triggers MRTF-A-SRF-CArG box, which activates transcription of smooth muscle-specific genes encoding contractile proteins in association with the regulatory phenotype of active renin secretion (left side). Without N-cad expression, β-catenin (signaling cascade in the middle) and growth factors (signaling cascade of right side) trigger a signaling cascade of growth factors of cell proliferation. MRTF-A, myocardin related transcription factor-A; SRF, serum response factor; MLC20, 20 kDa myosin light chain; PP1β, protein phosphatase 1β; FBS, fetal bovine serum; IGF-I, insulin-like growth factor-I; sm MHC, smooth muscle myosin heavy chain; nm MHC, nonmuscle myosin heavy chain.
Korean J Physiol Pharmacol 2022;26:479-499
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