Fig. 8. A schematic diagram of mechanism underlying DAT action on HepG2 cell survival.
TRAF6 functions as an E3 ligase. In the present study, TRAF6-modulated K63-linked polyubiquitination of APPL1 mediates the inhibitory effects of DAT on the survival of HepG2 cells by downregulating pro-survival signaling pathways such as STAT3, Akt, and Erk1/2 pathways. DAT, diallyl trisulfide; TRAF6, TNF receptor-associated factor 6; K63, Lys 63; APPL1, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1; Ub, ubiquitin.
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