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Fig. 7. Effect of overexpression of wild-type APPL1 on cell survival and proliferation in DAT-treated HepG2 cells. (A) Overexpression of wild-type APPL1 on cell viability. (B) Overexpression of wild-type APPL1 on cell proliferation. (C) Representative images of cell apoptosis by overexpression of wild-type APPL1 (×400). (D) Quantitative analysis of cell apoptosis in (C). (E) Impact of overexpression of wild-type APPL1 on cleaved caspase-3 levels. APPL1, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1; DAT, diallyl trisulfide. **p < 0.01 vs. control group; #p < 0.05, ##p < 0.01 vs. DAT-treated control group.
Korean J Physiol Pharmacol 2022;26:457-468 https://doi.org/10.4196/kjpp.2022.26.6.457
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