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Fig. 5. Effect of APPL1 K63R mutant on survival and proliferation of HepG2 cells. (A) Impact of K63R mutation of APPL1 on cell viability. (B) Impact of K63 mutation of APPL1 on cell proliferation. (C) Representative images of cell apoptosis by APPL1 K63R mutation (×400). (D) Quantitative analysis of cell apoptosis in (C). (E) Impact of APPL1 K63R mutation on cleaved caspase-3 levels. APPL1, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1; K63, Lys 63; WT, wild type. *p < 0.05, **p < 0.01 vs. control group.
Korean J Physiol Pharmacol 2022;26:457-468
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