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Fig. 4. Effect of APPL1 K63R mutant on phosphorylation of STAT3, Akt, and Erk1/2 in HepG2 cells. (A) Representative Western blot images. (B). Quantitative analysis of the ratio of phosphorylated proteins to the related-proteins. APPL1, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1; K63, Lys 63; OE, overexpression; Endo, endogenous; WT, wild type. *p < 0.05, **p < 0.01 vs. control group; ##p < 0.01 vs. APPL1 WT group.
Korean J Physiol Pharmacol 2022;26:457-468
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