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Fig. 6. Valdecoxib (Val) inhibited the PI3K/AKT/mTOR and MAPK pathways. Cells were treated with various concentrations of Val for 48 h. Total proteins were extracted and separated using SDS-PAGE. Antibodies against PI3K p85, p-PI3K, p-AKT, and p-mTOR were used to detect the expression of corresponding proteins (A, B) and the relative phosphorylation level was quantified (C, D). Vertical bars indicate means and standard errors (n = 3). MAPK, mitogen-activated protein kinase.
Korean J Physiol Pharmacol 2022;26:439-446
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