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Fig. 5. Valdecoxib (Val) induced DNA double-strand breaks and CHK2 activation. After Val treatment of FaDu cells, the localization and expression of Cdk1 and p-H2AX were examined using immunofluorescence imaging after staining with specific antibodies. The images were captured using a fluorescent microscope at 400× magnification (A). The expressions of p-CHK2, p53, and CDC25C were examined using Western blotting (B).
Korean J Physiol Pharmacol 2022;26:439-446
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