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Fig. 6. NLR family pyrin domain-containing 3 (NLRP3) reversed the discoid domain receptor 1 (DDR1) knockdown‒mediated downregulation of the nuclear transcription factor-κB (NF-κB)/NLRP3 pathway intermediaries at the transcript level (assessed using RT-qPCR). Transcript-level expression of (A) NLRP3, (B) NF-κB, (C) caspase-1, (D) gasdermin D (GSDMD), (E) interleukin (IL)-1β, (F) IL-18. Data are presented as mean ± SEM from 3 replicated cell experiments. Compared to control **p < 0.01. Compared to high glucose (HG), ##p < 0.01. Compared to siDDR1, &&p < 0.01.
Korean J Physiol Pharmacol 2022;26:427-438
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