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Fig. 5. Discoid domain receptor 1 (DDR1) knockdown resulted in the downregulation of the nuclear transcription factor-κB (NF-κB)/NLR family pyrin domain-containing 3 (NLRP3) pathway intermediaries at the protein level. (A) Bands corresponding to the expression of phosphorylated NF-κB (p-NF-κB) and NF-κB in the kidneys of DN rats. (B) Bands corresponding to the expression of NLRP3 in the kidneys of diabetic nephropathy (DN) rats. (C) Bands corresponding to the expression of p-NF-κB and NF-κB in HK-2 cells. (D) Bands corresponding to the expression of NLRP3 in HK-2 cells. Data are presented as mean ± SEM from 6 rats and 3 replicated cell experiments. Compared to control, **p < 0.01. Compared to high glucose (HG), #p < 0.05, ##p < 0.01.
Korean J Physiol Pharmacol 2022;26:427-438 https://doi.org/10.4196/kjpp.2022.26.6.427
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