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Fig. 6. The inhibition of TLR4/MyD88/NF-κB/NLRP3 cascade by Tanshinone IIA. (A) The mRNA levels of TLR4 and NLRP3 in the groups (n = 8 for each group). (B) The protein levels of TLR4, Myd88, p-NF-κB p65, NLRP3, and ASC (n = 3 for each group). (C) Representative immunohistochemical pictures of TLR4 and NLRP3 in cardiac tissues. Scale bar = 50 μm. The obtained data was revealed as the mean ± SD. CME, coronary microembolization; Tan-L, CME + low-dose Tan IIA (10 mg/kg); Tan-H, CME + high-dose Tan IIA (20 mg/kg). ***p < 0.001 vs. the sham group; ###p < 0.001 vs. the CME group.
Korean J Physiol Pharmacol 2022;26:335-345
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