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Fig. 6. BAC alleviated myocardial injury in vivo. (A) The heart infarct size was evaluated by TTC staining. ***p < 0.001 indicates the difference compared with sham group; ###p < 0.001 indicates the difference compared with ischemia reperfusion (IR) group. (B, C) The LDH and ROS levels were measured through the corresponding commercial kits. ***p < 0.001 indicates the difference compared with sham group; ###p < 0.001 indicates the difference compared with IR group. (D) The protein expression of p-AMPK, AMPK, and PGC-1α in heart tissues was assessed through Western blot. ***p < 0.001 indicates the difference compared with sham group; ###p < 0.001 indicates the difference compared with IR group. BAC, benzoylaconine; TTC, 2,3,5-triphenyltetrazolium chloride; LDH, lactate dehydrogenase; ROS, reactive oxygen species.
Korean J Physiol Pharmacol 2022;26:325-333 https://doi.org/10.4196/kjpp.2022.26.5.325
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