Fig. 1. Sleep deprivation and the pathogenesis of coronary heart disease.
NR1D1, nuclear receptor subfamily 1 group D member 1; CYP7A1, cholesterol 7α-hydroxylase; IRE1α ,Inositol-requiring enzyme-1α; CCL2, chemokine C-C motif ligand 2; CCR2, chemokine C-C-motif receptor 2; CCGs, CLOCK control genes; BMAL2, brain-muscle-ARNT-like protein-2; PAI-1, plasminogen activator inhibitor-1; TM, thrombomodulin; PI3K, phosphatidyl inositol-3 kinase; Akt, protein kinase B; eNOS, endothelial nitric oxide synthase; NO, nitric oxide; cGMP, cyclic guanosine monophosphate; cAMP, cyclic adenosine monophosphate; PKA, protein kinase A; TLR, toll-like receptor; NF-κB, nuclear factor kappa B.
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