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Fig. 6. Inhibitory effects of clozapine on voltage-dependent K+ (Kv)1.5, Kv2.1, and Kv7 subtypes. The representative Kv currents were elicited by applying 600-ms one-step depolarizing pulses of +60 mV from a holding potential of −80 mV. (A) Kv currents under control conditions, in the presence of DPO-1, and DPO-1 + clozapine. (B) Summary of the effects of DPO-1 on the inhibitory effect of clozapine on Kv currents. n = 5. NS, not significant (DPO-1 vs. DPO-1 + clozapine). (C) Kv currents under control conditions, in the presence of guangxitoxin, and in the presence of guangxitoxin + clozapine. (D) Summary of the effects of guangxitoxin on the inhibitory effect of clozapine on Kv currents. n = 4. *p < 0.05 (guangxitoxin vs. guangxitoxin + clozapine). (E) Kv currents under control conditions, in the presence of linopirdine, and in the presence of linopirdine + clozapine. (F) Summary of the effects of linopirdine on the inhibitory effect of clozapine on Kv currents. n = 5. *p < 0.05 (linopirdine vs. linopirdine + clozapine). Data are mean ± SEM.
Korean J Physiol Pharmacol 2022;26:277-285 https://doi.org/10.4196/kjpp.2022.26.4.277
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