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Fig. 5. Time course of recovery from clozapine-induced inhibition of voltage-dependent K+ (Kv) channels. The recovery time constants were measured by applying an identical twin pulse, as shown in the inset. A 150-ms depolarizing pre-pulse from −80 to +60 mV was followed by an identical second pulse with increasing intervals from 30 ms to 7 sec. Solid lines represent recovery of Kv currents in the absence (○) and presence (●) of 10 μM clozapine. n = 5. Data are mean ± SEM. *p < 0.05 (control vs. clozapine, at each time point).
Korean J Physiol Pharmacol 2022;26:277-285
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