Fig. 4. Use (state)-dependent inhibitory effect of clozapine on voltage-dependent K+ (Kv) channels.
Twenty repetitive depolarizing pulses from −80 to +60 mV with a duration of 150 ms were applied at frequencies of (A) 1 Hz and (B) 2 Hz, in the absence (○) and presence (●) of 10 μM clozapine. The peak currents of the Kv channels were normalized relative to the maximal peak current generated by the first pulse, and then plotted against the pulse numbers. n = 11. Data are mean ± SEM. *p < 0.05 (control vs. clozapine, at each pulse number).
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