Fig. 2. Concentration dependence of the effects of clozapine on voltage-dependent K+ (Kv) currents.
Current recordings of Kv channels were elicited by 600-ms one-step depolarizing pulses of +60 mV from a holding potential of −80 mV. (A) Superimposed current traces of Kv currents with increasing concentration of clozapine. (B) Concentration dependence of the inhibitory effect of clozapine. The inhibition (%) of Kv currents measured at the end of pulses is plotted against the clozapine concentration. The smooth line shows the best fit with a Hill equation. n = 11. Data are mean ± SEM.
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