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Fig. 1. Inhibitory effect of clozapine on voltage-dependent K+ (Kv) currents in rabbit coronary artery smooth muscle cells. Kv current traces were obtained in response to 600-ms step-depolarizing pulses from a holding potential of −80 mV in the (A) absence or (B) presence of 10 μM clozapine using the same cells. (C) The current–voltage (I–V) curves of the steady-state Kv currents in the absence (○) and presence (●) of 10 μM clozapine. n = 8. The “n” means the number of cells. Only one cell was used from a rabbit to reduce individual differences. Data are mean ± SEM. *p < 0.05 (control vs. clozapine, at each voltage).
Korean J Physiol Pharmacol 2022;26:277-285
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