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Fig. 5. Mitochondrial glutathione status in primary P5 and senescent P25 and P35 fibroblasts. Transcriptional activities of (A) glutathione peroxidase 1 (GPx1) and (B) glutathione reductase (GR), and enzyme activities of (C) GPx1 and (D) GR, along with levels of (E) reduced glutathione (GSH), (F) oxidized glutathione (GSSG), and (G) GSH/GSSG ratio in young (P5) and senescent (P25 and P35) confluent cells. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 indicate significant difference from control P5 values (n = 6).
Korean J Physiol Pharmacol 2022;26:263-275
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