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Fig. 2. Mitochondrial specific activities of TCA cycle enzymes in primary P5 and senescent P25 and P35 fibroblasts. Enzyme activities of (A) aconitase (can), (B) α-ketoglutarate dehydrogenase (α-KGDH), (C) succinate dehydrogenase (SDH), (D) malate dehydrogenase (MDH), (E) NAD+- isocitrate dehydrogenase (ICD), and (F) NADP+-ICD in young (P5) and senescent (P25 and P35) confluent cells. ***p < 0.001 and ****p < 0.0001 indicate significant difference from control P5 values (n = 6).
Korean J Physiol Pharmacol 2022;26:263-275
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