Fig. 5. Oxytocin induced vasoconstriction in the unstimulated rat’s aortic rings.
L-NAME (an inhibitor of nitric oxide synthase) (A) or endothelium removal (B) slightly enhanced oxytocin-induced vasoconstriction; (C) SQ29548 (an inhibitor of prostaglandin H2/thromboxane A2) did not affect oxytocin-induced vasoconstriction; (D) Atosiban completely abolished oxytocin-induced vasoconstriction; (E) PD98059 (an inhibitor of ERK1/2 activation) partially inhibited oxytocin-induced vasoconstriction; (F) Effect of oxytocin on phospho-ERK1/2 expression. OT, oxytocin; Ato, atosiban. n = 8. *p < 0.05 vs. control group, #p < 0.05 vs. oxytocin group.
© Korean J Physiol Pharmacol
