Fig. 2. Effects of PI3K inhibitor wortmannin or oxytocin/vasopressin 1a receptor antagonist atosiban on pAkt (tyr473) or peNOS (ser1177) in the cultured HUVECs.
Oxytocin dose-dependently increased Akt phosphorylation (A); Either wortmannin or atosiban significantly attenuated oxytocin-induced Akt (B) or eNOS phosphorylation (C). PI3K, phosphatidylinositol 3-kinase; HUVECs, human umbilical vein endothelial cells; OT, oxytocin; Wort, wortmannin; Ato, atosiban. n = 6, *p < 0.05 vs. control group, #p < 0.05 vs. oxytocin group.
© Korean J Physiol Pharmacol
