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Fig. 7. PI3K inhibitor LY294002 inhibits the migration of 16HBE cells. (A, B) The PI3K inhibitor LY294002 was used to study effects on the migration of 16HBE cells transfected with NC, miR-21 mimics, or PARP-1 siRNA. The experiments were replicated three times and presented as mean ± SD. 16HBE, Human bronchial epithelial cell; NC, normal control; miR-21, microRNA-21; PARP-1, poly (ADP-ribose) polymerase-1; siRNA, small interfering RNA; siPARP-1, PARP-1 siRNA; D, dimethylsulfoxide; LY, LY294002. Scale bars = 50 μm. *p < 0.05 vs. NC + D group, ***p < 0.001 vs. NC + D group, ††p < 0.01 vs. siPARP-1 + D group, †††p < 0.001 vs. miR21 + D group.
Korean J Physiol Pharmacol 2022;26:239-253 https://doi.org/10.4196/kjpp.2022.26.4.239
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