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Fig. 6. Effects of miR-21/PARP-1 on the PI3K/AKT signaling pathway. (A–C) Western blot analysis evaluated the expression of PI3K/AKT-signaling-pathway-related molecular proteins in 16HBE cells transfected with NC, miR-21 mimics, miR-21 inhibitor, PARP-1 plasmid, PARP-1 siRNA, miR-21 mimics + PARP-1 plasmid, or miR-21 inhibitor + PARP-1 siRNA after 48 h. The experiments were replicated three times and presented as mean ± SD. PARP-1, poly (ADP-ribose) polymerase-1; 16HBE, Human bronchial epithelial cell; NC, normal control; miR-21, microRNA-21; siRNA, small interfering RNA; siPARP-1, PARP-1 siRNA. *p < 0.05 vs. NC group, **p < 0.01 vs. NC group, ***p < 0.001 vs. NC group, p < 0.05 vs. miR21 or miR-21 inhibitor group, ††p < 0.01 vs. miR21 inhibitor group.
Korean J Physiol Pharmacol 2022;26:239-253
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