Fig. 3. Effects of miR-21/PARP-1 on migration of 16HBE cells.
(A, B) The 16HBE cells were transfected with NC, miR-21 mimics, miR-21 inhibitor, miR-21 mimics + PARP-1 plasmid, or miR-21 inhibitor + PARP-1 siRNA. Transwell assay was performed to assess the effects of miR-21/PARP-1 on the migration of 16HBE cells. Scale bars = 50 μm. The experiments were replicated three times and presented as mean ± SD. ***p < 0.001 vs. NC group, †††p < 0.001 vs. miR21 inhibitor group, ††††p < 0.0001 vs. miR21 group. (C) Images of the cell morphology 72 h post transfection. Scale bars = 50 μm. miR-21, microRNA-21; PARP-1, poly (ADP-ribose) polymerase-1; 16HBE, Human bronchial epithelial cell; NC, normal control; siRNA, small interfering RNA; siPARP-1, PARP-1 siRNA.
© Korean J Physiol Pharmacol