Fig. 1. Analogy between the change of concentration of sugar water after adding some water and that of haematocrit of blood after crystalloid fluid infusion.
(A) Change of concentration of sugar water after adding some water. Once you know the initial and final concentration of sugar water and the mass of water poured into it, you can tell the initial mass of the sugar water by building a linear equation (see Supplementary Text 1A for detailed explanation). (B) Change of haematocrit of blood after crystalloid fluid infusion. Likewise, if there is no blood or fluid loss via the circulation system, residual blood volume (RBV) would be calculable with serial haematocrits (Hct1 and Hct2) and the volume of crystalloid fluid infused in-between (N). The only difference from (A) is that only a certain fraction (k, which is approximately 0.25 for men) would be distributed into the intravascular volume (See Supplementary Text 1B for detailed explanation).
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